Efficient Antifouling Surface for Quantitative Surface Plasmon Resonance Based Biosensor Analysis

Efficient Antifouling Surface for Quantitative Surface Plasmon Resonance Based Biosensor Analysis

Non-specific binding to biosensor surfaces is a major obstacle to quantitative analysis of selective retention of analytes at immobilized target molecules. Although a range of chemical antifouling monolayers has been developed to address this problem, many macromolecular interactions still remain refractive to analysis due to the prevalent high degree of non-specific binding. In this manuscript...

Surface plasmon resonance biosensor

Advances in surface plasmon resonance biosensor analysis.

The number and diversity of surface plasmon resonance (SPR) biosensor applications continue to increase. Evolutions in instrument and sensor chip technology, experimental methodology, and data analysis are making it possible to examine a wider variety of biomolecular interactions in greater mechanistic detail. SPR biosensors are poised to make a significant impact in basic research and pharmace...

[Biosensor based on surface plasmon resonance].

Sensitivity analysis of a nanowire-based surface plasmon resonance biosensor in the presence of surface roughness.

We have investigated the effect of surface roughness on the sensitivity of conventional and nanowire-based surface plasmon resonance (SPR) biosensors. The theoretical research was conducted using rigorous coupled-wave analysis with Gaussian surface profiles of gold films determined by atomic force microscopy. The results suggest that, when surface roughness ranges near 1 nm, the sensitivity of ...